Definition:Use commas to enclose nouns or pronouns or a noun phrase in direct address.
Sentences:

1. Dr. Harvey, will you have time to see Timmy on Thursday?

2. I am delighted, Mrs. Smith, to hear that you will be joining us at the opera.

3. Will you please, sir, speak more loudly and perhaps project your voice a little?

4. Ladies and gentlemen, we have to decide on a nominee before we leave this room.

5. It was a pleasure to meet you.

Sir.Source: http://grammartips.homestead.com/directaddress.html

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